Epitalon (Epithalon) Research Hub
The Ala-Glu-Asp-Gly tetrapeptide: what it is, how it is handled in the lab, and lab-ready 10 mg and 50 mg vials.
What is epitalon?
Epitalon, also spelled epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG) and a molecular weight of about 390 Da. It was designed by the Russian gerontologist Vladimir Khavinson's group as a defined, synthetic version of epithalamin, a polypeptide extract of the bovine pineal gland.
Published work studies epitalon in telomerase and telomere biology, pineal and melatonin signalling, and ageing models in animals. Much of that literature comes from a small number of related research groups, and QSC supplies epitalon strictly for laboratory research.
Epitalon (epithalon) is a four-residue synthetic peptide (schematic).
Start here: research guides
Lab vials
Epitalon in 10 mg and 50 mg vials, supplied as lyophilized acetate salt in 10-vial packs.
Epitalon · Questions
What is epitalon?
+
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), with a molecular weight of about 390 Da and CAS number 307297-39-8. It was designed by Vladimir Khavinson's group as a defined version of epithalamin, a bovine pineal-gland extract.
Is epitalon the same as epithalon?
+
Yes. Epitalon and epithalon are two spellings of the same peptide. Epithalamin is different: it is the natural pineal extract, not the defined four-amino-acid peptide.
What is N-acetyl epitalon amidate?
+
N-acetyl epitalon amidate is a chemically modified analog with an acetylated N-terminus and an amidated C-terminus, designed to resist enzymatic degradation. It is a different compound and is not what QSC supplies under the epitalon listings.
What is epitalon studied for?
+
Published work falls into three areas: telomerase and telomere biology in cultured cells, pineal and melatonin signalling in aged animals, and lifespan and ageing models in rodents. Much of the literature comes from a small number of related groups, and independent replication is limited, so results are best treated as hypothesis-generating.
How do I reconstitute epitalon?
+
A typical stock is 2 to 5 mg/mL in sterile water. Concentration equals the milligrams in the vial divided by the millilitres of solvent: a 10 mg vial in 2 mL gives 5 mg/mL, and a 50 mg vial in 10 mL gives 5 mg/mL. Check that the vial can hold the volume before adding solvent. Refrigerate the solution and protect it from light.
How should epitalon be stored?
+
Keep lyophilized powder at -20°C for long-term storage, protected from light. Its half-life is short, so divide the reconstituted solution into single-use aliquots, refrigerate, and avoid repeated freeze-thaw cycles.
Should I choose the 10 mg or 50 mg vial?
+
Match the vial to how quickly you will use the reconstituted solution. The 10 mg vial suits small or slow protocols and limits waste; the 50 mg vial suits many replicates or arms in a short period. Each 10-vial pack contains ten identical vials from one lot.
Is epitalon approved for human use?
+
No. QSC sells epitalon strictly for laboratory research. Nothing on this site is medical advice or a recommendation for use in people or animals.
Published by QSC Peptidology for research-community reference. Not medical advice, and not a recommendation for human or veterinary use. All products are sold strictly for laboratory and research use only.