CJC-1295 and Ipamorelin Research Hub

CJC-1295 is a synthetic analog of growth hormone releasing hormone (GHRH 1-29) with four amino-acid substitutions that resist enzymatic degradation. It is studied as a GHRH-receptor agonist in growth-hormone-axis research and is available with or without the DAC albumin-binding linker.

The DAC form has a maleimidopropionic-acid linker that binds serum albumin through Cys-34, extending the half-life to about eight days and supporting continuous receptor activation. The no-DAC form lacks the linker and has a half-life of about 30 minutes, close to native GHRH's short pulse profile, and is used for pulsatile designs.

Ipamorelin is a five-residue synthetic pentapeptide that acts as a selective agonist at the ghrelin receptor (GHSR-1a), with a half-life of about two hours. In published animal studies it shows minimal effect on cortisol, prolactin or ACTH, which is the basis for calling it a selective GH releaser (CAS 170851-70-4, about 711.86 Da).

They act on separate receptors on pituitary somatotrophs, the GHRH receptor and the ghrelin receptor, and research on combined activation reports greater GH release than either alone. Ipamorelin's selectivity lets effects be attributed to GH-pathway activation rather than to other hormone changes, and the pairing has the deepest comparative literature.

It depends on the research question. The no-DAC form is most often paired with ipamorelin in pulse designs because the half-lives are closer. The DAC form is used where continuous GHRH-receptor activation is the variable, and its eight-day half-life then differs widely from ipamorelin's two hours.

CJC-1295 is typically reconstituted at 1 to 2 mg/mL and ipamorelin at 2 to 5 mg/mL, in sterile or bacteriostatic water. Concentration equals the milligrams in the vial divided by the millilitres of solvent, so a 5 mg ipamorelin vial in 2 mL gives 2.5 mg/mL. Refrigerate after reconstitution.

It is a single-vial research blend of CJC-1295 and ipamorelin, 10 mg or 20 mg total content per vial, for protocols that use both compounds together and prefer one reconstitution step over two. Protocols that keep the two compounds in separate vials can use the single-compound vials instead.

A COA for CJC-1295 no-DAC batch CJ-2608 (99.3% HPLC, measured mass 3368.0 Da against a theoretical 3367.90 Da) is published in the COA library. Reports are provided for batches where one exists.

Prices are per 10-vial pack of one size. Email us to arrange a smaller order at the same per-vial price. Orders of $1,000 or more ship free, and delivery is typically about 10 to 15 days, duties paid.

No. The research-grade material QSC supplies is not approved for human or veterinary use and is sold strictly for laboratory research. Nothing on this site is medical advice.